human RAD23A shRNA silencing Adenovirus

Name 
Ad-h-RAD23A-shRNA
Cat No 
shADV-220640
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human RAD23A.

shADV-220640
Ad-h-RAD23A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human RAD23A (RAD23 homolog A, nucleotide excision repair protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HHR23A; HR23A; RAD23, yeast homolog, A; UV excision repair protein RAD23 homolog A
Description (eCommerce)
Rad23A is also known as hHR23A and is the human homolog of the yeast rad23 protein. Rad23A is involved in postreplication repair of UV-damaged DNA. It may also play a role in ubiquitin-mediated proteolysis as it has been reported to associate with the 26S proteasome.
Description (Vector)
RAD23A is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. RAD23A plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
Gene ID
5886
Gene Name (eCommerce)
RAD23 homolog A, nucleotide excision repair protein
Gene Name (Vector)
RAD23 homolog A, nucleotide excision repair protein
Gene Symbol
RAD23A
HGNC ID
HGNC:9812
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1089
ORF Size (bp)
1089 bp
Protein Name (eCommerce)
UV excision repair protein RAD23 homolog A
RefSeq ID
NM_005053
RefSeq Synonyms
NM_005053, NM_001270363, NM_001270362, BC088364, BC014026,
Research Areas
Complexome,DNA Damage/Repair,Host-Virus Interactions,Proteasome,Ubiquitination
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,infectious_disease,cell_biology,genetics
Species
human
Target Sentence
Rad23A is also known as hHR23A and is the human homolog of the yeast rad23 protein. Rad23A is involved in postreplication repair of UV-damaged DNA. It may also play a role in ubiquitin-mediated proteolysis as it has been reported to associate with the 26S proteasome.
UniGene ID
Hs.643267
UniProt ID (eCommerce)
P54725

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.