human QKI shRNA silencing Adenovirus

Name 
Ad-h-QKI-shRNA
Cat No 
shADV-220466
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human QKI.

shADV-220466
Ad-h-QKI-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human QKI (QKI, KH domain containing RNA binding). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; hqkI; protein quaking; QK; QK1; QK3; QKI/LOC100132735 fusion; quaking homolog, KH domain RNA binding; RNA binding protein HQK
Description (eCommerce)
QKI is an RNA-binding protein and translational repressor important to embryogenesis and myelination. QKI exist as multiple isoforms with distinct functions that regulate pre-mRNA splicing and the stability of proteins central to oligodendrocyte differentiation. QKI has been identified as a candidate gene in schizophrenia.
Description (Vector)
QKI is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Four transcript variants encoding different isoforms have been found for this gene.
Gene ID
9444
Gene Name (eCommerce)
QKI, KH domain containing RNA binding
Gene Name (Vector)
QKI, KH domain containing RNA binding
Gene Symbol
QKI
HGNC ID
HGNC:21100
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1026
ORF Size (bp)
1026 bp
Protein Name (eCommerce)
Protein quaking
RefSeq ID
NM_006775
RefSeq Synonyms
NM_206855, NM_206854, NM_206853, NM_006775, NM_001301085, BC019917,
Research Areas
Cardiovascular,Gene Expression,mRNA Processing,mRNA Splicing,mRNA transport,Neurobiology,Nuclear Import/Export,RNA Binding,RNA Processing,RNA Transport,Translational Control,Transport
Research Areas (Faceted)
cardiovascular,genetics,transcription_translation,neurobiology,cell_biology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
QKI is an RNA-binding protein and translational repressor important to embryogenesis and myelination. QKI exist as multiple isoforms with distinct functions that regulate pre-mRNA splicing and the stability of proteins central to oligodendrocyte differentiation. QKI has been identified as a candidate gene in schizophrenia.
UniGene ID
Hs.593520
UniProt ID (eCommerce)
Q96PU8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.