human PVRL4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NECTIN4.
shADV-220421
Ad-h-PVRL4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NECTIN4 (nectin cell adhesion molecule 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EDSS1; LNIR; nectin-4; PRR4; PVRL4
Description (Vector)
PVRL4 encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
Gene ID
81607
Gene Name (Vector)
nectin cell adhesion molecule 4
Gene Symbol
NECTIN4
HGNC ID
HGNC:19688
ORF Size (aa)
1533
ORF Size (bp)
1533 bp
RefSeq ID
NM_030916
RefSeq Synonyms
NM_030916, BC010423,
Species
human
UniGene ID
Hs.492490
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.