human PVRL3 shRNA silencing Adenovirus

Name 
Ad-h-PVRL3-shRNA
Cat No 
shADV-220420
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NECTIN3.

shADV-220420
Ad-h-PVRL3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NECTIN3 (nectin cell adhesion molecule 3). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD113;CD113;CDW113;nectin 3;Nectin cell adhesion molecule 3;NECTIN-3;poliovirus receptor-related 3;poliovirus receptor-related protein 3;PPR3;PRR3;PVRL3;PVRR3
Description (eCommerce)
Nectin-3 is a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. Nectin-3 plays a role in ocular development involving the ciliary body. [taken from NCBI Entrez Gene (Gene ID: 25945)].
Description (Vector)
PVRL3 encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. PVRL3 plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants.
Gene ID
25945
Gene Name (eCommerce)
nectin cell adhesion molecule 3
Gene Name (Vector)
nectin cell adhesion molecule 3
Gene Symbol
NECTIN3
HGNC ID
HGNC:17664
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1101
ORF Size (bp)
1101 bp
Protein Name (eCommerce)
Nectin-3
RefSeq ID
NM_015480
RefSeq Synonyms
NM_015480, NM_001243288, NM_001243286, BC067808,
Research Areas
Cell Adhesion,Immunology,Neurobiology,Synapse
Research Areas (Faceted)
cell_biology,immunology,neurobiology
Species
human
Target Sentence
Nectin-3 is a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. Nectin-3 plays a role in ocular development involving the ciliary body. [taken from NCBI Entrez Gene (Gene ID: 25945)].
UniGene ID
Hs.293917
UniProt ID (eCommerce)
Q9NQS3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.