human PTTG1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PTTG1.
shADV-220373
Ad-h-PTTG1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PTTG1 (pituitary tumor-transforming 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EAP1; HPTTG; PTTG; TUTR1
Description (Vector)
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
Gene ID
9232
Gene Name (Vector)
pituitary tumor-transforming 1
Gene Symbol
PTTG1
HGNC ID
HGNC:9690
ORF Size (aa)
609
RefSeq ID
NM_004219
RefSeq Synonyms
NM_004219, NM_001282383, NM_001282382, BC128194, BC128193, BC112071, BC101834,
Species
human
UniGene ID
Hs.350966
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.