human PTPRK shRNA silencing Adenovirus

Name
Ad-h-PTPRK-shRNA

Cat No
shADV-220351

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human PTPRK.

shADV-220351

Ad-h-PTPRK-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PTPRK (protein tyrosine phosphatase, receptor type K). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

R-PTP-kappa

Description (Vector)

PTPRK is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.

Gene ID

5796

Gene Name (Vector)

protein tyrosine phosphatase, receptor type K

Gene Symbol

PTPRK

HGNC ID

HGNC:9674

ORF Size (aa)

4389

ORF Size (bp)

4389 bp

RefSeq ID

NM_002844

RefSeq Synonyms

NM_002844, NM_001291984, NM_001291983, NM_001291982, NM_001291981, NM_001135648, BC144513, BC144512, BC140775, BC063596,

Species

human

UniGene ID

Hs.155919

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.