human PTPRJ shRNA silencing Adenovirus

Name 
Ad-h-PTPRJ-shRNA
Cat No 
shADV-220348
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PTPRJ.

shADV-220348
Ad-h-PTPRJ-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PTPRJ (protein tyrosine phosphatase, receptor type J). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD148; DEP1; HPTPeta; R-PTP-ETA; SCC1
Description (Vector)
PTPRJ is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
5795
Gene Name (Vector)
protein tyrosine phosphatase, receptor type J
Gene Symbol
PTPRJ
HGNC ID
HGNC:9673
ORF Size (aa)
4014
ORF Size (bp)
4014 bp
RefSeq ID
NM_002843
RefSeq Synonyms
NM_002843, NM_001098503, BC160125,
Species
human
UniGene ID
Hs.318547

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.