human PSMC3 shRNA silencing Adenovirus

26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; 26S proteasome regulatory subunit 6A; human immunodeficiency virus tat transactivator binding protein-1; proteasome (prosome, macropain) 26S subunit, ATPase, 3; Proteasome 26S subunit ATPase 3; proteasome subunit P50; Tat-binding protein 1; TBP1; TBP-1; testicular secretory protein Li 42

Tat-binding protein 1 (TBP1) is a regulatory subunit (subunit 6A) of the 26S protease involved in the ATP-dependent degradation of ubiquitinated proteins. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

5702

proteasome 26S subunit, ATPase 3

proteasome 26S subunit, ATPase 3

PSMC3

HGNC:9549

9606.0

1320

1320 bp

26S protease regulatory subunit 6A

NM_002804

NM_002804, BC106920, BC073165, BC008713,

Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cell Cycle,Complexome,DNA Damage/Repair,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,NF-kB Signaling,Notch Signaling,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Proteasome,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Ubiquitination,Wnt Signaling

signal_transduction,immunology,cell_biology,signal_transduction,immunology,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,signal_transduction,metabolism,neurobiology,signal_transduction,immunology,developmental_biology,neurobiology,cell_biology,genetics,transcription_translation,signal_transduction,immunology,genetics,transcription_translation,developmental_biology

human

Tat-binding protein 1 (TBP1) is a regulatory subunit (subunit 6A) of the 26S protease involved in the ATP-dependent degradation of ubiquitinated proteins. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.

Hs.250758

P17980