human PSENEN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PSENEN.
shADV-220069
Ad-h-PSENEN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PSENEN (presenilin enhancer gamma-secretase subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MDS033; MSTP064; PEN-2; PEN2
Description (Vector)
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Gene ID
55851
Gene Name (Vector)
presenilin enhancer gamma-secretase subunit
Gene Symbol
PSENEN
HGNC ID
HGNC:30100
ORF Size (aa)
306
RefSeq ID
NM_172341
RefSeq Synonyms
NM_172341, NM_001281532, BC009575,
Species
human
UniGene ID
Hs.534465
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.