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human PRKCQ shRNA silencing Adenovirus

Name 
Ad-h-PRKCQ-shRNA
Cat No 
shADV-219867
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PRKCQ.

shADV-219867
Ad-h-PRKCQ-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PRKCQ (protein kinase C theta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
nPKC-theta; PRKCT; protein kinase C theta type
Description (eCommerce)
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. Protein kinase C theta type (PRKCQ) is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factor [taken from NCBI Entrez Gene (Gene ID: 5588)].
Description (Vector)
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Gene ID
5588
Gene Name (eCommerce)
protein kinase C theta
Gene Name (Vector)
protein kinase C theta
Gene Symbol
PRKCQ
HGNC ID
HGNC:9410
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2121
ORF Size (bp)
2121 bp
Protein Name (eCommerce)
Protein kinase C theta type
RefSeq ID
NM_006257
RefSeq Synonyms
NM_006257, NM_001323267, NM_001323266, NM_001323265, NM_001282645, NM_001282644, NM_001242413, BC113359, BC101465,
Research Areas
Aging,Apoptosis,Axon Guidance,B-cell Receptor Signaling,Cancer,Cardiology,Cardiovascular,Cell Cycle,EPO Signaling,Fc Receptor Signaling,Glioma,GPCR Signaling,Host-Virus Interactions,Hypoxia,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Neurobiology,NFAT Signaling,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,Ubiquitination,VEGF Signaling,Wnt Signaling,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,genetics,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. Protein kinase C theta type (PRKCQ) is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factor [taken from NCBI Entrez Gene (Gene ID: 5588)].
UniGene ID
Hs.498570
UniProt ID (eCommerce)
Q04759

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.