human PRDX3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PRDX3.
shADV-219772
Ad-h-PRDX3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PRDX3 (peroxiredoxin 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
antioxidant protein 1; AOP1; AOP-1; epididymis secretory sperm binding protein; HBC189; MER5; peroxiredoxin III; Peroxiredoxin-3; PRO1748; protein MER5 homolog; prx-III; SP-22; thioredoxin-dependent peroxide reductase, mitochondrial
Description (eCommerce)
Peroxiredoxin-3 (PRDX3) is involved in redox regulation of the cell [taken from NCBI Entrez Gene (Gene ID: 10935)].
Description (Vector)
PRDX3 encodes a protein with antioxidant function and is localized in the mitochondrion. PRDX3 shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.
Gene ID
10935
Gene Name (eCommerce)
peroxiredoxin 3
Gene Name (Vector)
peroxiredoxin 3
Gene Symbol
PRDX3
HGNC ID
HGNC:9354
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
771
Protein Name (eCommerce)
Thioredoxin-dependent peroxide reductase, mitochondrial
RefSeq ID
NM_006793
RefSeq Synonyms
NM_014098, NM_006793, NM_001302272, BC111397, BC059169, BC022373, BC021691, BC009601, BC008435, BC007062, BC002685,
Research Areas
Apoptosis,Mitochondrion,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology
Species
human
Target Sentence
Peroxiredoxin-3 (PRDX3) is involved in redox regulation of the cell [taken from NCBI Entrez Gene (Gene ID: 10935)].
UniGene ID
Hs.523302
UniProt ID (eCommerce)
P30048
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.