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human PPP4C shRNA silencing Adenovirus

Name 
Ad-h-PPP4C-shRNA
Cat No 
shADV-219681
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PPP4C.

shADV-219681
Ad-h-PPP4C-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PPP4C (protein phosphatase 4 catalytic subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; PP4; PP4C; PPH3; PPP4; PPX; PP-X; protein phosphatase 4 (formerly X), catalytic subunit; Protein phosphatase X; protein phosphatase X, catalytic subunit; serine/threonine-protein phosphatase 4 catalytic subunit
Description (eCommerce)
PPP4C, also known as PPX, is the catalytic subunit of the PP4 serine/threonine protein phosphatase. PP4 is a holoenzyme that is comprised of the PPP4C catalytic subunit in association with the PP4-R1 or PP4-R2 regulatory subunits. PP4 has been demonstrated to directly interact with and activate NF-kappaB. PP4 also has been demonstrated to interact with histone deacetylase HDAC3 to influence transcription and to serve a role in microtubule organization during mitosis. Signaling through the MAPK and JNK-1 pathway has also been demonstrated to involve PP4.
Gene ID
5531
Gene Name (eCommerce)
protein phosphatase 4 catalytic subunit
Gene Name (Vector)
protein phosphatase 4 catalytic subunit
Gene Symbol
PPP4C
HGNC ID
HGNC:9319
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
924
ORF Size (bp)
924 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 4 catalytic subunit
RefSeq ID
NM_002720
RefSeq Synonyms
NM_002720, NM_001303507, NM_001303506, NM_001303504, NM_001303503, BC001416,
Research Areas
Cytoskeleton,DNA Damage/Repair,Kinase/Phosphatase,NF-kB Signaling,Phosphatase,Signal Transduction
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
PPP4C, also known as PPX, is the catalytic subunit of the PP4 serine/threonine protein phosphatase. PP4 is a holoenzyme that is comprised of the PPP4C catalytic subunit in association with the PP4-R1 or PP4-R2 regulatory subunits. PP4 has been demonstrated to directly interact with and activate NF-kappaB. PP4 also has been demonstrated to interact with histone deacetylase HDAC3 to influence transcription and to serve a role in microtubule organization during mitosis. Signaling through the MAPK and JNK-1 pathway has also been demonstrated to involve PP4.
UniGene ID
Hs.534338
UniProt ID (eCommerce)
P60510

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.