human PPP2R1A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PPP2R1A.
shADV-219649
Ad-h-PPP2R1A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
medium tumor antigen-associated 61 KDA protein; MRD36; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; PP2AA; PP2AAALPHA; PP2A-Aalpha; PR65A; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; protein phosphatase 2, regulatory subunit A, alpha; protein phosphatase 2A structural subunit A, alpha isoform; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; testicular secretory protein Li 1
Description (eCommerce)
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R1A is the alpha isoform of the 65kd structural subunit of PP2A. The PP2A catalytic subunit complexed with PPP2R1A can associate with various regulatory subunits to form trimeric holoenzymes with distinct activities.
Description (Vector)
PPP2R1A encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. PPP2R1A encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
Gene ID
5518
Gene Name (eCommerce)
protein phosphatase 2 scaffold subunit Aalpha
Gene Name (Vector)
protein phosphatase 2 scaffold subunit Aalpha
Gene Symbol
PPP2R1A
HGNC ID
HGNC:9302
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1770
ORF Size (bp)
1770 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
RefSeq ID
NM_014225
RefSeq Synonyms
NM_014225, BC001537,
Research Areas
Apoptosis,Cell Cycle,Cytoskeleton,DNA Damage/Repair,DNA Replication,FGF Signaling,Gene Expression,GPCR Signaling,Hippo Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,Kinase/Phosphatase,Meiosis,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PLK1 Signaling,RNA Processing,Signal Transduction,TGF-beta Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. It is a trimeric holoenzyme that is comprised of a catalytic, structural, and regulatory subunit. PPP2R1A is the alpha isoform of the 65kd structural subunit of PP2A. The PP2A catalytic subunit complexed with PPP2R1A can associate with various regulatory subunits to form trimeric holoenzymes with distinct activities.
UniGene ID
Hs.467192
UniProt ID (eCommerce)
P30153
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.