human PPP2CB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PPP2CB.
shADV-219648
Ad-h-PPP2CB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PPP2CB (protein phosphatase 2 catalytic subunit beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PP2Abeta; PP2A-beta; PP2CB; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2A catalytic subunit, beta isoform; protein phosphatase type 2A catalytic subunit; serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; testicular tissue protein Li 146
Description (eCommerce)
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. PP2A encodes the beta isoform of the catalytic subunit (PP2CB). Chk2 has been shown to be negatively regulated and dephosphorylated by PP2A. Several proteins have been shown to associate with PP2A and regulate its activity such as eRF1, Hox11, CK2, and Igbp1/alpha4. Rapamycin has been shown to dissociate PP2A from alpha-4 and inhibit proliferation. This result suggests an alternative positive regulatory role of PP2A in cell proliferation.
Description (Vector)
PPP2CB encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. PPP2CB encodes a beta isoform of the catalytic subunit.
Gene ID
5516
Gene Name (eCommerce)
protein phosphatase 2 catalytic subunit beta
Gene Name (Vector)
protein phosphatase 2 catalytic subunit beta
Gene Symbol
PPP2CB
HGNC ID
HGNC:9300
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
930
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
RefSeq ID
NM_001009552
RefSeq Synonyms
NM_001009552, BC012022,
Research Areas
Apoptosis,Cell Cycle,Cytoskeleton,DNA Damage/Repair,DNA Replication,FGF Signaling,Gene Expression,GPCR Signaling,Hippo Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Kinase/Phosphatase,Meiosis,Metabolism/Metabolic Process,Neurobiology,NGF Signaling,Phosphatase,PI3K/Akt Signaling,Signal Transduction,TGF-beta Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PP2A is a major serine/threonine phosphatase that is implicated in the negative control of cell cycle progression. PP2A encodes the beta isoform of the catalytic subunit (PP2CB). Chk2 has been shown to be negatively regulated and dephosphorylated by PP2A. Several proteins have been shown to associate with PP2A and regulate its activity such as eRF1, Hox11, CK2, and Igbp1/alpha4. Rapamycin has been shown to dissociate PP2A from alpha-4 and inhibit proliferation. This result suggests an alternative positive regulatory role of PP2A in cell proliferation.
UniGene ID
Hs.491440
UniProt ID (eCommerce)
P62714
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.