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human POU3F2 shRNA silencing Adenovirus

Name 
Ad-h-POU3F2-shRNA
Cat No 
shADV-219477
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human POU3F2.

shADV-219477
Ad-h-POU3F2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human POU3F2 (POU class 3 homeobox 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
brain-2; brain-specific homeobox/POU domain protein 2; BRN2; brn-2; nervous system-specific octamer-binding transcription factor N-Oct-3; N-Oct3; OCT7; oct-7; octamer-binding protein 7; octamer-binding transcription factor 7; OTF7; OTF-7; POU domain, class 3, transcription factor 2; POUF3
Description (eCommerce)
Brain-specific homeobox/POU domain protein 2, (Brn-2) is a transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Brn-2 positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P20265].
Description (Vector)
POU3F2 encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells.
Gene ID
5454
Gene Name (eCommerce)
POU class 3 homeobox 2
Gene Name (Vector)
POU class 3 homeobox 2
Gene Symbol
POU3F2
HGNC ID
HGNC:9215
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1332
ORF Size (bp)
1332 bp
Protein Name (eCommerce)
POU domain, class 3, transcription factor 2
RefSeq ID
NM_005604
RefSeq Synonyms
NM_005604, BC051699,
Research Areas
Axonogenesis,Neurobiology,Neurodevelopment,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
Brain-specific homeobox/POU domain protein 2, (Brn-2) is a transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Brn-2 positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (by similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P20265].
UniGene ID
Hs.182505
UniProt ID (eCommerce)
P20265

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.