human PLCH1 shRNA silencing Adenovirus

Name
Ad-h-PLCH1-shRNA

Cat No
shADV-219133

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Human PLCH1.

shADV-219133

Ad-h-PLCH1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PLCH1 (phospholipase C eta 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

No

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; phosphoinositide phospholipase C-eta-1; Phospholipase C-eta-1; phospholipase C-eta1a; phospholipase C-eta1b; phospholipase C-like 3; phospholipase C-like protein 3; PLC eta 1; PLC-eta-1; PLCL3; PLC-L3

Description (eCommerce)

PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]) [taken from NCBI Entrez Gene (Gene ID: 23007)].

Description (Vector)

PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 (PubMed 15702972)).(supplied by OMIM, Jun 2009)

Gene ID

23007

Gene Name (eCommerce)

phospholipase C eta 1

Gene Name (Vector)

phospholipase C eta 1

Gene Symbol

PLCH1

HGNC ID

HGNC:29185

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

4968

ORF Size (bp)

4968 bp

Protein Name (eCommerce)

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

RefSeq ID

NM_001130960

RefSeq Synonyms

NM_014996, NM_001130961, NM_001130960, BC113950,

Research Areas

Metabolism/Metabolic Process,Signal Transduction

Research Areas (Faceted)

cell_biology,metabolism,signal_transduction

Species

human

Target Sentence

PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]) [taken from NCBI Entrez Gene (Gene ID: 23007)].

UniGene ID

Hs.567423

UniProt ID (eCommerce)

Q4KWH8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.