human PLAUR shRNA silencing Adenovirus

Name 
Ad-h-PLAUR-shRNA
Cat No 
shADV-219111
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PLAUR.

shADV-219111
Ad-h-PLAUR-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PLAUR (plasminogen activator, urokinase receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD87; CD87; monocyte activation antigen Mo3; UPAR; U-PAR; u-plasminogen activator receptor form 2; URKR; urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor
Description (eCommerce)
Urokinase plasminogen activator surface receptor (UPAR) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation and mediates the proteolysis-independent signal transduction activation effects of U-PA. UPAR is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q03405].
Description (Vector)
PLAUR encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Gene ID
5329
Gene Name (eCommerce)
plasminogen activator, urokinase receptor
Gene Name (Vector)
plasminogen activator, urokinase receptor
Gene Symbol
PLAUR
HGNC ID
HGNC:9053
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1008
ORF Size (bp)
1008 bp
Protein Name (eCommerce)
Urokinase plasminogen activator surface receptor
RefSeq ID
NM_002659
RefSeq Synonyms
NM_002659, NM_001301037, NM_001005377, NM_001005376, BC002788,
Research Areas
Apoptosis,Cancer,FGF Signaling,Gene Expression,Metabolism/Metabolic Process,Signal Transduction,Translational Control
Research Areas (Faceted)
cancer,cell_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
Urokinase plasminogen activator surface receptor (UPAR) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation and mediates the proteolysis-independent signal transduction activation effects of U-PA. UPAR is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q03405].
UniGene ID
Hs.466871
UniProt ID (eCommerce)
Q03405

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.