human PIK3C2B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PIK3C2B.
shADV-218939
Ad-h-PIK3C2B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C2-PI3K
Description (Vector)
PIK3C2B belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
Gene ID
5287
Gene Name (Vector)
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Gene Symbol
PIK3C2B
HGNC ID
HGNC:8972
ORF Size (aa)
4905
ORF Size (bp)
4905 bp
RefSeq ID
NM_002646
RefSeq Synonyms
NM_002646, BC144342, BC136645, BC132876,
Species
human
UniGene ID
Hs.497487
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.