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human PHF6 shRNA silencing Adenovirus

Name 
Ad-h-PHF6-shRNA
Cat No 
shADV-218822
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PHF6.

shADV-218822
Ad-h-PHF6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PHF6 (PHD finger protein 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BFLS; BORJ; CENP-31; centromere protein 31; PHD finger protein 6; PHD-like zinc finger protein
Description (eCommerce)
PHF6 a member of the PHD (plant homeodomain)-like zinc-finger family of proteins and is suggested to function as an important transcription factor. PHF6 is ubiquitously expressed and localizes to the cell nucleus with prominent expression in the nucleolus. Expression in the nucleolus indicates an importance to ribosome biogenesis. Mutations in PHF6 are the cause of Borgeson-Forssman-Lehman syndrome (BFLS), an X-linked syndrome characterized by mental retardation, hypogonadism, hypometabolism, obesity, gynecomastia, and several forms of facial anomalies.
Description (Vector)
PHF6 is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms.
Gene ID
84295
Gene Name (eCommerce)
PHD finger protein 6
Gene Name (Vector)
PHD finger protein 6
Gene Symbol
PHF6
HGNC ID
HGNC:18145
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
939
ORF Size (bp)
939 bp
Protein Name (eCommerce)
PHD finger protein 6
RefSeq ID
NM_032335
RefSeq Synonyms
NM_032458, NM_032335, NM_001015877, BC005994,
Research Areas
Epilepsy,Neurobiology,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,neurobiology,transcription_translation
Species
human
Target Sentence
PHF6 a member of the PHD (plant homeodomain)-like zinc-finger family of proteins and is suggested to function as an important transcription factor. PHF6 is ubiquitously expressed and localizes to the cell nucleus with prominent expression in the nucleolus. Expression in the nucleolus indicates an importance to ribosome biogenesis. Mutations in PHF6 are the cause of Borgeson-Forssman-Lehman syndrome (BFLS), an X-linked syndrome characterized by mental retardation, hypogonadism, hypometabolism, obesity, gynecomastia, and several forms of facial anomalies.
UniGene ID
Hs.356501
UniProt ID (eCommerce)
Q8IWS0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.