human PEX5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PEX5.
shADV-218646
Ad-h-PEX5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PEX5 (peroxisomal biogenesis factor 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PBD2A; PBD2B; PTS1-BP; PTS1R; PXR1; RCDP5
Description (Vector)
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
5830
Gene Name (Vector)
peroxisomal biogenesis factor 5
Gene Symbol
PEX5
HGNC ID
HGNC:9719
ORF Size (aa)
1896
ORF Size (bp)
1896 bp
RefSeq ID
NM_000319
RefSeq Synonyms
NM_001300789, NM_001131026, NM_001131025, NM_001131024, NM_001131023, NM_000319, BC010621,
Species
human
UniGene ID
Hs.567327
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.