human PEX19 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PEX19.
shADV-218641
Ad-h-PEX19-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PEX19 (peroxisomal biogenesis factor 19). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D1S2223E; HK33; PBD12A; PMP1; PMPI; PXF; PXMP1
Description (Vector)
PEX19 is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.
Gene ID
5824
Gene Name (Vector)
peroxisomal biogenesis factor 19
Gene Symbol
PEX19
HGNC ID
HGNC:9713
ORF Size (aa)
900
RefSeq ID
NM_002857
RefSeq Synonyms
NM_002857, NM_001193644, BC000496,
Species
human
UniGene ID
Hs.517232
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.