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human PEX14 shRNA silencing Adenovirus

Name 
Ad-h-PEX14-shRNA
Cat No 
shADV-218638
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PEX14.

shADV-218638
Ad-h-PEX14-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PEX14 (peroxisomal biogenesis factor 14). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
dJ734G22.2; NAPP2; NF-E2 associated polypeptide 2; PBD13A; peroxin-14; peroxisomal membrane anchor protein PEX14; peroxisomal membrane anchor protein Pex14p; peroxisomal membrane protein PEX14; Pex14p; PTS1 receptor docking protein; PTS1 receptor-docking protein
Description (eCommerce)
Peroxisomal biogenesis factor 14 (PEX14) is an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [taken from NCBI Entrez Gene (Gene ID: 5195)].
Description (Vector)
PEX14 encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.
Gene ID
5195
Gene Name (eCommerce)
peroxisomal biogenesis factor 14
Gene Name (Vector)
peroxisomal biogenesis factor 14
Gene Symbol
PEX14
HGNC ID
HGNC:8856
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1134
ORF Size (bp)
1134 bp
Protein Name (eCommerce)
Peroxisomal membrane protein PEX14
RefSeq ID
NM_004565
RefSeq Synonyms
NM_004565, BC006327,
Research Areas
Neurobiology,Transcription Factor/Regulator,Transport
Research Areas (Faceted)
cell_biology,neurobiology,transcription_translation
Species
human
Target Sentence
Peroxisomal biogenesis factor 14 (PEX14) is an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [taken from NCBI Entrez Gene (Gene ID: 5195)].
UniGene ID
Hs.149983
UniProt ID (eCommerce)
O75381

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.