human PDZD3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PDZD3.
shADV-218573
Ad-h-PDZD3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PDZD3 (PDZ domain containing 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IKEPP; NHERF4; PDZK2
Description (Vector)
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 (PubMed 11950846)).(supplied by OMIM, Mar 2008)
Gene ID
79849
Gene Name (Vector)
PDZ domain containing 3
Gene Symbol
PDZD3
HGNC ID
HGNC:19891
ORF Size (aa)
1476
ORF Size (bp)
1476 bp
RefSeq ID
NM_024791
RefSeq Synonyms
NM_024791, NM_001168468, BC029042,
Species
human
UniGene ID
Hs.374726
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.