human PDCD6IP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PDCD6IP.
shADV-218448
Ad-h-PDCD6IP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PDCD6IP (programmed cell death 6 interacting protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AIP1; ALG-2 interacting protein 1; ALG-2-interacting protein 1; ALG-2-interacting protein X; ALIX; apoptosis-linked gene 2-interacting protein X; dopamine receptor interacting protein 4; DRIP4; HP95; PDCD6-interacting protein; programmed cell death 6-interacting protein
Description (eCommerce)
ALIX (ALG-2 interacting protein X) is thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of ALIX can block apoptosis. ALIX has been shown to bind to the PDCD6 (programmed cell death 6 interacting protein), a protein required for apoptosis, in a calcium-dependent manner. ALIX also binds to endophilins, proteins that regulate membrane shape during endocytosis [taken from NCBI Entrez Gene (Gene ID: 10015].
Description (Vector)
PDCD6IP encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. PDCD6IP product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
Gene ID
10015
Gene Name (eCommerce)
programmed cell death 6 interacting protein
Gene Name (Vector)
programmed cell death 6 interacting protein
Gene Symbol
PDCD6IP
HGNC ID
HGNC:8766
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2622
ORF Size (bp)
2622 bp
Protein Name (eCommerce)
Programmed cell death 6-interacting protein
RefSeq ID
NM_013374
RefSeq Synonyms
NM_013374, NM_001256192, NM_001162429, BC068454, BC020066,
Research Areas
Apoptosis,Cell Cycle,Cell Division,Cytoskeleton,EGFR Signaling,Host-Virus Interactions,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction
Species
human
Target Sentence
ALIX (ALG-2 interacting protein X) is thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of ALIX can block apoptosis. ALIX has been shown to bind to the PDCD6 (programmed cell death 6 interacting protein), a protein required for apoptosis, in a calcium-dependent manner. ALIX also binds to endophilins, proteins that regulate membrane shape during endocytosis [taken from NCBI Entrez Gene (Gene ID: 10015].
UniGene ID
Hs.475896
UniProt ID (eCommerce)
Q8WUM4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.