human PCCA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PCCA.
shADV-218314
Ad-h-PCCA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PCCA (propionyl-CoA carboxylase alpha subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
pccA complementation group; PCCase alpha subunit; PCCase subunit alpha; propanoyl-CoA:carbon dioxide ligase alpha subunit; Propanoyl-CoA:carbon dioxide ligase subunit alpha; propionyl CoA carboxylase, alpha polypeptide; propionyl Coenzyme A carboxylase, alpha polypeptide; propionyl-CoA carboxylase alpha chain, mitochondrial; propionyl-CoA carboxylase alpha subunit
Description (eCommerce)
Propionyl CoA carboxylase, alpha polypeptide (PCCA)is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA functions as the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia [taken from NCBI Entrez Gene (Gene ID: 5095)].
Description (Vector)
PCCA is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
5095
Gene Name (eCommerce)
propionyl-CoA carboxylase subunit alpha
Gene Name (Vector)
propionyl-CoA carboxylase alpha subunit
Gene Symbol
PCCA
HGNC ID
HGNC:8653
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2112
ORF Size (bp)
2112 bp
Protein Name (eCommerce)
Propionyl-CoA carboxylase alpha chain, mitochondrial
RefSeq ID
NM_000282
RefSeq Synonyms
NM_001178004, NM_001127692, NM_000282, BC000140,
Research Areas
Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Propionyl CoA carboxylase, alpha polypeptide (PCCA)is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA functions as the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia [taken from NCBI Entrez Gene (Gene ID: 5095)].
UniGene ID
Hs.80741
UniProt ID (eCommerce)
P05165
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.