human PAXIP1 shRNA silencing Adenovirus

Name
Ad-h-PAXIP1-shRNA

Cat No
shADV-218284

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human PAXIP1.

shADV-218284

Ad-h-PAXIP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PAXIP1 (PAX interacting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

70

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CAGF28; CAGF29; PACIP1; PAX interacting (with transcription-activation domain) protein 1; PAX transactivation activation domain-interacting protein; PAX transcription activation domain interacting protein 1 like; PAX-interacting protein 1; PAXIP1L; protein encoded by CAG trinucleotide repeats; PTIP; TNRC2

Description (eCommerce)

Pax transactivation domain-interacting protein (PTIP) is implicated in the DNA damage response. PTIP interacts with 53BP1 and PA1 and is part of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, a novel protein PA-1 MLL3, MLL4, and UTX. PTIP is therefore suggested to have a role in the regulation of gene expression.

Description (Vector)

PAXIP1 is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.

Gene ID

22976

Gene Name (eCommerce)

PAX interacting protein 1

Gene Name (Vector)

PAX interacting protein 1

Gene Symbol

PAXIP1

HGNC ID

HGNC:8624

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2274

ORF Size (bp)

2274 bp

Protein Name (eCommerce)

PAX-interacting protein 1

RefSeq ID

NM_007349

RefSeq Synonyms

NM_007349, BC033781,

Research Areas

Cardiovascular,DNA Damage/Repair,Histone Modification,Transcription Factor/Regulator

Research Areas (Faceted)

cardiovascular,cell_biology,genetics,transcription_translation

Species

human

Target Sentence

Pax transactivation domain-interacting protein (PTIP) is implicated in the DNA damage response. PTIP interacts with 53BP1 and PA1 and is part of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, a novel protein PA-1 MLL3, MLL4, and UTX. PTIP is therefore suggested to have a role in the regulation of gene expression.

UniGene ID

Hs.443881

UniProt ID (eCommerce)

Q6ZW49

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.