human PAK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PAK2.
shADV-218153
Ad-h-PAK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PAK2 (p21 (RAC1) activated kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; PAK-2; PAK65; PAKgamma; S6/H4 kinase; serine/threonine-protein kinase PAK 2
Description (eCommerce)
PAK2 (p21-activated kinase 2) is part of the family of PAK serine/threonine p21-activating protein kinases involved in cell survival, migration, and invasion. The PAK family of proteins mediates signals from extracellular stimuli to the cytoplasm and nucleus via its association with the small GTP-binding proteins Cdc42 and Rac. PAK2 has been shown to play a specific role in apoptosis and cytoskeletal dynamics. During caspase-mediated apoptosis, PAK2 is cleaved and the C-terminal myristoylated fragment mediates cell death and actin reorganization via the JNK signaling pathway.
Description (Vector)
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Gene ID
5062
Gene Name (eCommerce)
p21 (RAC1) activated kinase 2
Gene Name (Vector)
p21 (RAC1) activated kinase 2
Gene Symbol
PAK2
HGNC ID
HGNC:8591
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1575
ORF Size (bp)
1575 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase PAK 2
RefSeq ID
NM_002577
RefSeq Synonyms
NM_002577, BC069613,
Research Areas
Apoptosis,Axon Guidance,Breast Cancer,Cancer,CD95/FAS Signaling,Cytoskeleton,EPO Signaling,Fc Receptor Signaling,HGF Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kidney Cancer,Kinase/Phosphatase,MAPK Signaling,Neurobiology,Neurodevelopment,RAC1 Signaling,Response to Virus,Signal Transduction,T-cell Receptor Signaling,Translational Control,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PAK2 (p21-activated kinase 2) is part of the family of PAK serine/threonine p21-activating protein kinases involved in cell survival, migration, and invasion. The PAK family of proteins mediates signals from extracellular stimuli to the cytoplasm and nucleus via its association with the small GTP-binding proteins Cdc42 and Rac. PAK2 has been shown to play a specific role in apoptosis and cytoskeletal dynamics. During caspase-mediated apoptosis, PAK2 is cleaved and the C-terminal myristoylated fragment mediates cell death and actin reorganization via the JNK signaling pathway.
UniGene ID
Hs.518530
UniProt ID (eCommerce)
Q13177
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.