human OTX2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human OTX2.
shADV-218011
Ad-h-OTX2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human OTX2 (orthodenticle homeobox 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CPHD6; MCOPS5
Description (Vector)
OTX2 encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). OTX2 is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.
Gene ID
5015
Gene Name (Vector)
orthodenticle homeobox 2
Gene Symbol
OTX2
HGNC ID
HGNC:8522
ORF Size (aa)
894
RefSeq ID
NM_021728
RefSeq Synonyms
NM_172337, NM_021728, NM_001270525, NM_001270524, NM_001270523, BC032579,
Species
human
UniGene ID
Hs.288655
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.