human OAT shRNA silencing Adenovirus

Name 
Ad-h-OAT-shRNA
Cat No 
shADV-217312
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human OAT.

shADV-217312
Ad-h-OAT-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human OAT (ornithine aminotransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GACR; gyrate atrophy; HOGA; OATASE; OKT; ornithine aminotransferase, mitochondrial; ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase; ornithine-oxo-acid aminotransferase; testicular tissue protein Li 130
Description (eCommerce)
Ornithine aminotransferase (OAT) is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy [taken from NCBI Entrez Gene (Gene ID: 4942)].
Description (Vector)
OAT encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.
Gene ID
4942
Gene Name (eCommerce)
ornithine aminotransferase
Gene Name (Vector)
ornithine aminotransferase
Gene Symbol
OAT
HGNC ID
HGNC:8091
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1320
ORF Size (bp)
1320 bp
Protein Name (eCommerce)
Ornithine aminotransferase, mitochondrial
RefSeq ID
NM_000274
RefSeq Synonyms
NM_001322974, NM_001322971, NM_001322970, NM_001322969, NM_001322968, NM_001322967, NM_001322966, NM_001322965, NM_001171814, NM_000274, BC016928, BC000964,
Research Areas
Metabolism/Metabolic Process,Mitochondrion,Neurobiology
Research Areas (Faceted)
cell_biology,metabolism,neurobiology
Species
human
Target Sentence
Ornithine aminotransferase (OAT) is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy [taken from NCBI Entrez Gene (Gene ID: 4942)].
UniGene ID
Hs.523332
UniProt ID (eCommerce)
P04181

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.