human NUMBL shRNA silencing Adenovirus

Name 
Ad-h-NUMBL-shRNA
Cat No 
shADV-217230
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NUMBL.

shADV-217230
Ad-h-NUMBL-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NUMBL (NUMB like, endocytic adaptor protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CAG3A; CTG3a; NBL; numb homolog-like; NUMBLIKE; numb-like protein; NUMBR; NUMB-R; numb-related protein; TNRC23
Description (eCommerce)
NUMBL [numb (drosophila) homolog-like] is functionally related to NUMB, a protein that plays an essential role in the determination of cell fate for sensory organ and neural development. Polyglutamine repeats in the NUMBL gene have been associated with schizophrenia in two unrelated populations.
Gene ID
9253
Gene Name (eCommerce)
NUMB like, endocytic adaptor protein
Gene Name (Vector)
NUMB like, endocytic adaptor protein
Gene Symbol
NUMBL
HGNC ID
HGNC:8061
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1830
ORF Size (bp)
1830 bp
Protein Name (eCommerce)
Numb-like protein
RefSeq ID
NM_004756
RefSeq Synonyms
NM_004756, NM_001289980, NM_001289979, BC167835, BC001794,
Research Areas
Axonogenesis,Cardiology,Cardiovascular,Neurobiology,Neurodevelopment,Neurogenesis,Notch Signaling,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology,cardiovascular,neurobiology,developmental_biology,signal_transduction
Species
human
Target Sentence
NUMBL [numb (drosophila) homolog-like] is functionally related to NUMB, a protein that plays an essential role in the determination of cell fate for sensory organ and neural development. Polyglutamine repeats in the NUMBL gene have been associated with schizophrenia in two unrelated populations.
UniGene ID
Hs.326953
UniProt ID (eCommerce)
Q9Y6R0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.