human NUDT1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NUDT1.
shADV-217198
Ad-h-NUDT1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NUDT1 (nudix hydrolase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MTH1
Description (Vector)
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
Gene ID
4521
Gene Name (Vector)
nudix hydrolase 1
Gene Symbol
NUDT1
HGNC ID
HGNC:8048
ORF Size (aa)
471
RefSeq ID
NM_002452
RefSeq Synonyms
NM_198954, NM_198953, NM_198952, NM_198950, NM_198949, NM_198948, NM_002452, BC065367, BC051375, BC040144, BC014618,
Species
human
UniGene ID
Hs.534331
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.