human NUB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NUB1.
shADV-217175
Ad-h-NUB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NUB1 (negative regulator of ubiquitin like proteins 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BS4; NUB1L; NYREN18
Description (Vector)
NUB1 encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.
Gene ID
51667
Gene Name (Vector)
negative regulator of ubiquitin like proteins 1
Gene Symbol
NUB1
HGNC ID
HGNC:17623
ORF Size (aa)
1806
ORF Size (bp)
1806 bp
RefSeq ID
NM_016118
RefSeq Synonyms
NM_016118, NM_001243351, BC046354,
Species
human
UniGene ID
Hs.647082
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.