human NHLRC1 shRNA silencing Adenovirus

Name
Ad-h-NHLRC1-shRNA

Cat No
shADV-216689

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human NHLRC1.

shADV-216689

Ad-h-NHLRC1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NHLRC1 (NHL repeat containing E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

bA204B7.2; EPM2A; EPM2B; MALIN

Description (Vector)

NHLRC1 is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as progressive myoclonic epilepsy type 2 (EPM2).

Gene ID

378884

Gene Name (Vector)

NHL repeat containing E3 ubiquitin protein ligase 1

Gene Symbol

NHLRC1

HGNC ID

HGNC:21576

ORF Size (aa)

1188

ORF Size (bp)

1188 bp

RefSeq ID

NM_198586

RefSeq Synonyms

NM_198586, BC103890, BC103889, BC103888,

Species

human

UniGene ID

Hs.348351

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.