human NFX1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human NFX1.
shADV-216662
Ad-h-NFX1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human NFX1 (nuclear transcription factor, X-box binding 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NFX2; nuclear transcription factor, X box-binding protein 1; TEG-42; Tex42; transcriptional repressor NF-X1
Description (eCommerce)
NFX1 (nuclear transcription factor, X box-binding protein 1) binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 of NFX1 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q12986].
Description (Vector)
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
Gene ID
4799
Gene Name (eCommerce)
nuclear transcription factor, X-box binding 1
Gene Name (Vector)
nuclear transcription factor, X-box binding 1
Gene Symbol
NFX1
HGNC ID
HGNC:7803
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3363
ORF Size (bp)
3363 bp
Protein Name (eCommerce)
Transcriptional repressor NF-X1
RefSeq ID
NM_002504
RefSeq Synonyms
NM_147134, NM_147133, NM_002504, NM_001318758, BC012151,
Research Areas
Cancer,Gene Expression,Host-Virus Interactions,Immunology,mRNA Processing,mRNA Splicing,mRNA Transport,RNA Processing,RNA Transport,Transcription Factor/Regulator,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,genetics,transcription_translation,infectious_disease,immunology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
NFX1 (nuclear transcription factor, X box-binding protein 1) binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 of NFX1 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q12986].
UniGene ID
Hs.413074
UniProt ID (eCommerce)
Q12986
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.