human NCOA6 shRNA silencing Adenovirus

Name 
Ad-h-NCOA6-shRNA
Cat No 
shADV-216425
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NCOA6.

shADV-216425
Ad-h-NCOA6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NCOA6 (nuclear receptor coactivator 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Activating signal cointegrator 2; activating signal cointegrator-2; AIB3; amplified in breast cancer protein 3; amplified in breast cancer-3 protein; ASC2; ASC-2; cancer-amplified transcriptional coactivator ASC-2; NRC; NRC RAP250; nuclear receptor coactivator 6; nuclear receptor coactivator RAP250; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein; Peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; RAP250; thyroid hormone receptor binding protein; Thyroid hormone receptor-binding protein; TRBP
Description (eCommerce)
Activating signal co-integrator 2 (ASC2) functions as a hormone-dependent transcriptional coactivator in cooperation with nuclear receptors such as steroids, retinoids, thyroid hormone, vitamin D3 and prostanoids. ASC2 also interacts with basal transcription factors and may also influence gene expression through its association with histone modifiers. ASC2 has been identified as an amplified gene in breast and other human cancers.
Description (Vector)
NCOA6 is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
23054
Gene Name (eCommerce)
nuclear receptor coactivator 6
Gene Name (Vector)
nuclear receptor coactivator 6
Gene Symbol
NCOA6
HGNC ID
HGNC:15936
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6192
ORF Size (bp)
6192 bp
Protein Name (eCommerce)
Nuclear receptor coactivator 6
RefSeq ID
NM_014071
RefSeq Synonyms
NM_014071, NM_001318240, NM_001242539, BC136272,
Research Areas
Brain Development,Cardiac Development,Cardiology,Cardiovascular,Chromatin Remodeling,DNA Damage/Repair,DNA Replication,Estrogen Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Nuclear Receptor Coactivators,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,genetics,transcription_translation,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Activating signal co-integrator 2 (ASC2) functions as a hormone-dependent transcriptional coactivator in cooperation with nuclear receptors such as steroids, retinoids, thyroid hormone, vitamin D3 and prostanoids. ASC2 also interacts with basal transcription factors and may also influence gene expression through its association with histone modifiers. ASC2 has been identified as an amplified gene in breast and other human cancers.
UniGene ID
Hs.368971
UniProt ID (eCommerce)
Q14686

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.