human NCOA1 shRNA silencing Adenovirus

Name 
Ad-h-NCOA1-shRNA
Cat No 
shADV-216416
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NCOA1.

shADV-216416
Ad-h-NCOA1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NCOA1 (nuclear receptor coactivator 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
bHLHe42; bHLHe74; class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; NCoA-1; nuclear receptor coactivator 1; Protein Hin-2; renal carcinoma antigen NY-REN-52; RIP160; SRC1; SRC-1; Steroid receptor coactivator 1; steroid receptor coactivator-1
Description (eCommerce)
Steroid receptor coactivator 1 (SRC1) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC1contains histone acetyltransferase (HAT) activities and may facilitate transcription through chromatin remodeling. SRCs associate with p300/CBP-associated factor and CREB binding protein (CBP) as part of a multisubunit coactivating complex.
Description (Vector)
NCOA1 acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
8648
Gene Name (eCommerce)
nuclear receptor coactivator 1
Gene Name (Vector)
nuclear receptor coactivator 1
Gene Symbol
NCOA1
HGNC ID
HGNC:7668
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4326
ORF Size (bp)
4326 bp
Protein Name (eCommerce)
Nuclear receptor coactivator 1
RefSeq ID
NM_003743
RefSeq Synonyms
NM_147233, NM_147223, NM_003743, BC111534, BC111533,
Research Areas
Acyltransferase,Apoptosis,Cancer,Histone Modification,Interleukin Signaling,Leptin Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Nuclear Receptor Coactivators,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Steroid receptor coactivator 1 (SRC1) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC1contains histone acetyltransferase (HAT) activities and may facilitate transcription through chromatin remodeling. SRCs associate with p300/CBP-associated factor and CREB binding protein (CBP) as part of a multisubunit coactivating complex.
UniGene ID
Hs.596314
UniProt ID (eCommerce)
Q15788

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.