human NCKIPSD shRNA silencing Adenovirus

Name 
Ad-h-NCKIPSD-shRNA
Cat No 
shADV-216406
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NCKIPSD.

shADV-216406
Ad-h-NCKIPSD-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NCKIPSD (NCK interacting protein with SH3 domain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
54 kDa VacA-interacting protein; 54 kDa vimentin-interacting protein; 90 kDa SH3 protein interacting with Nck; AF3P21; dia interacting protein; dia-interacting protein 1; diaphanous protein interacting protein; Diaphanous protein-interacting protein; DIP; DIP1; DIP-1; NCK-interacting protein with SH3 domain; ORF1; SH3 adapter protein SPIN90; SH3 protein interacting with Nck, 90 kDa; SPIN90; VIP54; WASLBP; WASP-interacting SH3-domain protein; WISH; wiskott-Aldrich syndrome protein-interacting protein
Description (eCommerce)
SPIN90 plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene encoding SPIN90, NCKIPSD, is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves NCKIPSD and the myeloid/lymphoid leukemia gene [taken from NCBI Entrez Gene (GeneID: 51517)].
Description (Vector)
NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.
Gene ID
51517
Gene Name (eCommerce)
NCK interacting protein with SH3 domain
Gene Name (Vector)
NCK interacting protein with SH3 domain
Gene Symbol
NCKIPSD
HGNC ID
HGNC:15486
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2148
ORF Size (bp)
2148 bp
Protein Name (eCommerce)
NCK-interacting protein with SH3 domain
RefSeq ID
NM_016453
RefSeq Synonyms
NM_184231, NM_016453, BC026280, BC016052,
Research Areas
Cancer,Cytoskeleton,Immunology,Innate Immunity,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
SPIN90 plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene encoding SPIN90, NCKIPSD, is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves NCKIPSD and the myeloid/lymphoid leukemia gene [taken from NCBI Entrez Gene (GeneID: 51517)].
UniGene ID
Hs.655006
UniProt ID (eCommerce)
Q9NZQ3

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.