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human MYO3A shRNA silencing Adenovirus

Name 
Ad-h-MYO3A-shRNA
Cat No 
shADV-216216
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MYO3A.

shADV-216216
Ad-h-MYO3A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MYO3A (myosin IIIA). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DFNB30
Description (Vector)
MYO3A belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. MYO3A plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.
Gene ID
53904
Gene Name (Vector)
myosin IIIA
Gene Symbol
MYO3A
HGNC ID
HGNC:7601
ORF Size (aa)
4848
ORF Size (bp)
4848 bp
RefSeq ID
NM_017433
RefSeq Synonyms
NM_017433, BC156362,
Species
human
UniGene ID
Hs.662630

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.