human MRVI1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MRVI1.
shADV-215883
Ad-h-MRVI1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MRVI1 (murine retrovirus integration site 1 homolog). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IRAG; JAW1L
Description (Vector)
MRVI1 is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Gene ID
10335
Gene Name (Vector)
murine retrovirus integration site 1 homolog
Gene Symbol
MRVI1
HGNC ID
HGNC:7237
ORF Size (aa)
1794
ORF Size (bp)
1794 bp
RefSeq ID
NM_001098579
RefSeq Synonyms
NM_130385, NM_001206881, NM_001206880, NM_001100167, NM_001100163, NM_001098579, BC117127,
Species
human
UniGene ID
Hs.501898
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.