human MRPS12 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MRPS12.
shADV-215845
Ad-h-MRPS12-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MRPS12 (mitochondrial ribosomal protein S12). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MPR-S12; MT-RPS12; RPMS12; RPS12; RPSM12
Description (Vector)
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein.
Gene ID
6183
Gene Name (Vector)
mitochondrial ribosomal protein S12
Gene Symbol
MRPS12
HGNC ID
HGNC:10380
ORF Size (aa)
417
RefSeq ID
NM_021107
RefSeq Synonyms
NM_033363, NM_033362, NM_021107, BC007499, BC006424, BC001617,
Species
human
UniGene ID
Hs.411125
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.