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human MPP1 shRNA silencing Adenovirus

Name 
Ad-h-MPP1-shRNA
Cat No 
shADV-215717
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MPP1.

shADV-215717
Ad-h-MPP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MPP1 (membrane palmitoylated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
55 kDa erythrocyte membrane protein; AAG12; aging-associated gene 12; DXS552E; EMP55; erythrocyte membrane protein p55; Membrane protein, palmitoylated 1; membrane protein, palmitoylated 1, 55kDa; migration-related gene 1; MRG1; p55; palmitoylated erythrocyte membrane protein; PEMP
Description (eCommerce)
MPP1/p55 is essential regulator of neutrophil polarity. MPP1/p55 regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q00013].
Description (Vector)
MPP1 encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. MPP1 product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
4354
Gene Name (eCommerce)
membrane palmitoylated protein 1
Gene Name (Vector)
membrane palmitoylated protein 1
Gene Symbol
MPP1
HGNC ID
HGNC:7219
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1401
ORF Size (bp)
1401 bp
Protein Name (eCommerce)
55 kDa erythrocyte membrane protein
RefSeq ID
NM_002436
RefSeq Synonyms
NM_002436, NM_001166462, NM_001166461, NM_001166460, BC002392,
Research Areas
Cytoskeleton,Kinase/Phosphatase,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
MPP1/p55 is essential regulator of neutrophil polarity. MPP1/p55 regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q00013].
UniGene ID
Hs.496984
UniProt ID (eCommerce)
Q00013

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.