human MMP14 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MMP14.
shADV-215576
Ad-h-MMP14-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MMP14 (matrix metallopeptidase 14). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS
Description (Vector)
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Gene ID
4323
Gene Name (Vector)
matrix metallopeptidase 14
Gene Symbol
MMP14
HGNC ID
HGNC:7160
ORF Size (aa)
1749
ORF Size (bp)
1749 bp
RefSeq ID
NM_004995
RefSeq Synonyms
NM_004995, BC064803,
Species
human
UniGene ID
Hs.2399
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.