human MME shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MME.
shADV-215559
Ad-h-MME-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MME (membrane metalloendopeptidase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CALLA; CD10; CMT2T; NEP; SCA43; SFE
Description (Vector)
MME encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.
Gene ID
4311
Gene Name (Vector)
membrane metalloendopeptidase
Gene Symbol
MME
HGNC ID
HGNC:7154
ORF Size (aa)
2253
ORF Size (bp)
2253 bp
RefSeq ID
NM_000902
RefSeq Synonyms
NM_007289, NM_007288, NM_007287, NM_000902, BC143465, BC101658, BC101632,
Species
human
UniGene ID
Hs.307734
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.