human MAVS shRNA silencing Adenovirus

Name 
Ad-h-MAVS-shRNA
Cat No 
shADV-215077
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MAVS.

shADV-215077
Ad-h-MAVS-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MAVS (mitochondrial antiviral signaling protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; CARDIF; IFN-B promoter stimulator 1; interferon beta promoter stimulator protein 1; IPS1; IPS-1; MAVS; mitochondrial antiviral-signaling protein; putative NF-kappa-B-activating protein 031N; virus-induced signaling adaptor; virus-induced-signaling adapter; VISA
Description (eCommerce)
Mitochondrial Antiviral-Signaling Protein (MAVS), also known as Virus-Induced Signaling Adaptor (VISA), is an adaptor protein that functions in the activation of the nuclear factor KappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) to mediate host innate immune responses against double-stranded RNA viral infection. MAVS (VISA) is localized to the outer mitochondrial membrane. Hepatitis C virus NS3/4A protease cleaves MAVS as part of an immune-evasion strategy.
Description (Vector)
MAVS encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
57506
Gene Name (eCommerce)
mitochondrial antiviral signaling protein
Gene Name (Vector)
mitochondrial antiviral signaling protein
Gene Symbol
MAVS
HGNC ID
HGNC:29233
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1623
ORF Size (bp)
1623 bp
Protein Name (eCommerce)
Mitochondrial antiviral-signaling protein
RefSeq ID
NM_020746
RefSeq Synonyms
NM_020746, NM_001206491, BC044952,
Research Areas
Cancer,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Mitochondrion,NF-kB Signaling,Response to Virus,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Mitochondrial Antiviral-Signaling Protein (MAVS), also known as Virus-Induced Signaling Adaptor (VISA), is an adaptor protein that functions in the activation of the nuclear factor KappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) to mediate host innate immune responses against double-stranded RNA viral infection. MAVS (VISA) is localized to the outer mitochondrial membrane. Hepatitis C virus NS3/4A protease cleaves MAVS as part of an immune-evasion strategy.
UniGene ID
Hs.570362
UniProt ID (eCommerce)
Q7Z434

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.