human MATR3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human MATR3.
shADV-215076
Ad-h-MATR3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human MATR3 (matrin 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALS21; matrin-3; MPD2; VCPDM; vocal cord and pharyngeal weakness with distal myopathY
Description (eCommerce)
Matrin 3 is a nuclear matrix protein that has been observed to mediate multiple cellular processes. Matrin 3 can function to withhold defective RNAs within the nucleus by anchoring them to the nuclear matrix and modulate the promoter activity of genes proximal to matrix/scaffold attachment region (MAR/SAR). Matrin 3 has also been demonstrated to be the main PKA substrate following NMDA receptor activation in NMDA-induced neuronal cell death.
Description (Vector)
This locus encodes a nuclear matrix protein. Mutations at this locus have been associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts with an upstream locus have been described. Related pseuodgenes have been defined on chr1 and chrX.
Gene ID
9782
Gene Name (eCommerce)
matrin 3
Gene Name (Vector)
matrin 3
Gene Symbol
MATR3
HGNC ID
HGNC:6912
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2544
ORF Size (bp)
2544 bp
Protein Name (eCommerce)
Matrin-3
RefSeq ID
NM_018834
RefSeq Synonyms
NM_199189, NM_018834, NM_001282278, NM_001194956, NM_001194955, NM_001194954, BC015031,
Research Areas
Immunology,RNA Binding,RNA Processing,Zinc-finger
Research Areas (Faceted)
immunology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Matrin 3 is a nuclear matrix protein that has been observed to mediate multiple cellular processes. Matrin 3 can function to withhold defective RNAs within the nucleus by anchoring them to the nuclear matrix and modulate the promoter activity of genes proximal to matrix/scaffold attachment region (MAR/SAR). Matrin 3 has also been demonstrated to be the main PKA substrate following NMDA receptor activation in NMDA-induced neuronal cell death.
UniGene ID
Hs.268939
UniProt ID (eCommerce)
P43243
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.