human MAPK3 shRNA silencing Adenovirus

ERK1; ERK-1; ERT2; extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; HS44KDAP; HUMKER1A; insulin-stimulated MAP2 kinase; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; microtubule-associated protein 2 kinase; mitogen-activated protein kinase 3; P44ERK1; p44-ERK1; P44MAPK; p44-MAPK; PRKM3

Extracellular signal-regulated kinase 1 (ERK1/p44), also known as mitogen-activated protein kinase 3 (MAPK3), and extracellular signal-regulated kinase 2 (ERK2/p42), also known as mitogen-activated protein kinase 1 (MAPK1), are part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK1 is very similar in sequence to ERK2/p42 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles.

MAPK3 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.

5595

mitogen-activated protein kinase 3

mitogen-activated protein kinase 3

MAPK3

HGNC:6877

9606.0

1140

1140 bp

Mitogen-activated protein kinase 3

NM_002746

NM_002746, NM_001109891, NM_001040056, BC013992,

Alzheimer's Disease,Angiogenesis,Apoptosis,Axon Guidance,B-cell Receptor Signaling,BDNF Signaling,Bladder Cancer,Breast Cancer,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Colorectal Cancer,Cytokine Signaling,Cytoskeleton,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Glioma,GnRH Signaling,Golgi Apparatus,GPCR Signaling,HGF Signaling,HIF-1 Signaling,Histone Modification,Host-Virus Interactions,IFN Signaling,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kidney Cancer,Kinase/Phosphatase,Leptin Signaling,Leukemia,Lung Cancer,MAPK Signaling,Meiosis,Mitochondrion,mTOR Signaling,Neurobiology,Neurodegeneration,Neurodevelopment,NFAT Signaling,NGF Signaling,Notch Signaling,PDGF Signaling,Phospho-specific,PI3K/Akt Signaling,Prolactin Signaling,Prostate Cancer,RANKL-RANK Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,TPO Signaling,TRAIL Signaling,Transcription Factor/Regulator,TSH Signaling,TSLP Signaling,TWEAK Signaling,VEGF Signaling,Viral Carcinogenesis,Wnt Signaling

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

human

Extracellular signal-regulated kinase 1 (ERK1/p44), also known as mitogen-activated protein kinase 3 (MAPK3), and extracellular signal-regulated kinase 2 (ERK2/p42), also known as mitogen-activated protein kinase 1 (MAPK1), are part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK1 is very similar in sequence to ERK2/p42 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles.

Hs.861

P27361