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human MAF shRNA silencing Adenovirus

Name 
Ad-h-MAF-shRNA
Cat No 
shADV-214788
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human MAF.

shADV-214788
Ad-h-MAF-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human MAF (MAF bZIP transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; AYGRP; CCA4; c-MAF; c-maf proto-oncogene; CTRCT21; proto-oncogene c-Maf; T lymphocyte c-maf long form; transcription factor Maf; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog
Description (eCommerce)
c-Maf is part of the Maf family of transcription factors that possess a conserved basic region and a leucine zipper domain that mediate DNA and protein-protein binding and plays an important role in tissue-specific gene regulation and cell differentiation. c-Maf is a transcriptional activator of interleukin 4 and 10 in T-cells, and is involved in lens fiber cell differentiation. c-Maf translocation has been observed in human multiple myeloma and may be oncogenic.
Description (Vector)
MAF is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
4094
Gene Name (eCommerce)
MAF bZIP transcription factor
Gene Name (Vector)
MAF bZIP transcription factor
Gene Symbol
MAF
HGNC ID
HGNC:6776
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1122
ORF Size (bp)
1122 bp
Protein Name (eCommerce)
Transcription factor Maf
RefSeq ID
NM_005360
RefSeq Synonyms
NM_005360, NM_001031804, BC081542,
Research Areas
Cancer,Immunology,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,immunology,cancer,transcription_translation
Species
human
Target Sentence
c-Maf is part of the Maf family of transcription factors that possess a conserved basic region and a leucine zipper domain that mediate DNA and protein-protein binding and plays an important role in tissue-specific gene regulation and cell differentiation. c-Maf is a transcriptional activator of interleukin 4 and 10 in T-cells, and is involved in lens fiber cell differentiation. c-Maf translocation has been observed in human multiple myeloma and may be oncogenic.
UniGene ID
Hs.134859
UniProt ID (eCommerce)
O75444

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.