human LTA4H shRNA silencing Adenovirus

Name 
Ad-h-LTA4H-shRNA
Cat No 
shADV-214658
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human LTA4H.

shADV-214658
Ad-h-LTA4H-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human LTA4H (leukotriene A4 hydrolase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Leukotriene A(4) hydrolase; leukotriene A-4 hydrolase; LTA-4 hydrolase; testicular secretory protein Li 27
Description (eCommerce)
Leukotriene A4 Hydrolase/LTA4H is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD) [taken from NCBI Entrez Gene (Gene ID: 4048)].
Gene ID
4048
Gene Name (eCommerce)
leukotriene A4 hydrolase
Gene Name (Vector)
leukotriene A4 hydrolase
Gene Symbol
LTA4H
HGNC ID
HGNC:6710
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1836
ORF Size (bp)
1836 bp
Protein Name (eCommerce)
Leukotriene A-4 hydrolase
RefSeq ID
NM_000895
RefSeq Synonyms
NM_001256644, NM_001256643, NM_000895, BC032528,
Research Areas
Immunology,Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,immunology,metabolism
Species
human
Target Sentence
Leukotriene A4 Hydrolase/LTA4H is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD) [taken from NCBI Entrez Gene (Gene ID: 4048)].
UniGene ID
Hs.524648
UniProt ID (eCommerce)
P09960

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.