human LRDD shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human PIDD1.
shADV-214474
Ad-h-LRDD-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human PIDD1 (p53-induced death domain protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LRDD; PIDD
Description (Vector)
PIDD contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.
Gene ID
55367
Gene Name (Vector)
p53-induced death domain protein 1
Gene Symbol
PIDD1
HGNC ID
HGNC:16491
ORF Size (aa)
2682
ORF Size (bp)
2682 bp
RefSeq ID
NM_145886
RefSeq Synonyms
NM_145887, NM_145886, BC014904,
Species
human
UniGene ID
Hs.592290
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.