human LPHN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ADGRL1.
shADV-214455
Ad-h-LPHN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ADGRL1 (adhesion G protein-coupled receptor L1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CIRL1; CL1; LEC2; LPHN1
Description (Vector)
LPHN1 encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.
Gene ID
22859
Gene Name (Vector)
adhesion G protein-coupled receptor L1
Gene Symbol
ADGRL1
HGNC ID
HGNC:20973
ORF Size (aa)
4410
ORF Size (bp)
4410 bp
RefSeq ID
NM_014921
RefSeq Synonyms
NM_014921, NM_001008701, BC168378,
Species
human
UniGene ID
Hs.654658
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.